Key result
Peak frequency-guided cardioneuroablation eliminates syncope recurrence at 3 months in pediatric mixed vasovagal syncope.
Why the study?
The management of refractory vasovagal syncope in young patients is challenging, and cardioneuroablation guided by precise localization techniques is a potential alternative.
Does cardioneuroablation guided by peak frequency mapping prevent syncope in pediatric patients with vasovagal syncope?
Case Report (n=1)
Does cardioneuroablation guided by peak frequency mapping prevent syncope in pediatric patients with vasovagal syncope?
Cardioneuroablation guided by peak frequency mapping using omnipolar technology is a feasible and potentially effective technique for treating refractory vasovagal syncope in pediatric patients.
Supports PF-guided CNA feasibility in pediatric refractory VVS; leaves open efficacy confirmation in prospective trials.
BACKGROUND: The management of refractory vasovagal syncope (VVS) in young patients presents a challenge, and cardioneuroablation (CNA) is a potential alternative. Real-time peak frequency (PF) spectral mapping with continuous-wavelet transform enables precise localization of ganglionated plexi. CASE SUMMARY: A 12-year-old woman who presented with mixed-type VVS underwent CNA. Electroanatomic mapping was performed using a mapping system equipped with omnipolar technology near field. PF maps identified the right superior, right inferior, and posteromedial left ganglionated plexi, which were subsequently ablated. Postablation electrophysiological evaluation improved significantly. During the 3-month follow-up, the patient remained free of syncope. DISCUSSION: This case details the first stand-alone application of omnipolar technology near field-based PF mapping to guide CNA in a pediatric patient with VVS. It demonstrates the feasibility of this precise technique, providing a methodological reference for pediatric CNA. TAKE-HOME MESSAGE: In young patients with VVS, CNA guided by PF mapping is a viable strategy.
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Wang et al. (2026) conducted a case report in Mixed-type vasovagal syncope (n=1). Cardioneuroablation guided by peak frequency mapping was evaluated on Syncope recurrence. Cardioneuroablation guided by peak frequency mapping successfully treated mixed-type vasovagal syncope in a 12-year-old patient, who had 0 syncope recurrences during a 3-month follow-up.
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