Key result
Higher PRECISE-HBR score linked to ~15% higher odds of post-TAVI major bleeding per point.
Why the study?
The clinical utility of the PRECISE-HBR score for predicting bleeding risk and hospitalization burden after TAVI remains uncertain.
Does higher PRECISE-HBR score predict major bleeding and prolonged hospitalization in patients undergoing TAVI?
Observational (n=184)
No
Does higher PRECISE-HBR score predict major bleeding and prolonged hospitalization in patients undergoing TAVI?
Odds Ratio: 1.15 (95% CI 1.09–1.22)
p-value: p=<0.001
The PRECISE-HBR score, originally designed for patients undergoing percutaneous coronary intervention, is associated with a stepwise increase in major bleeding and hospital length of stay when applied to patients undergoing TAVI.
PRECISE-HBR score was associated with bleeding and prolonged stay after TAVI; leaves open its utility for risk stratification pending validation.
Background/aim: The PRECISE-HBR score was developed to estimate bleeding risk after percutaneous coronary intervention, but its clinical utility in patients undergoing transcatheter aortic valve implantation (TAVI) remains uncertain. We evaluated its association with major bleeding and hospitalization burden after TAVI. Materials and methods: This ambispective, single-center observational study included 184 consecutive patients undergoing TAVI. The patients were categorized by PRECISE-HBR score (≤22, 23-26, and ≥27) for descriptive comparisons. Receiver operating characteristic analyses were used to assess the discriminative performance of PRECISE-HBR and the Society of Thoracic Surgeons score for major bleeding, prolonged hospitalization, and in-hospital mortality. Binary logistic regression was utilized to evaluate associations between each one-point increase in PRECISE-HBR and clinical outcomes, while correlation analyses were used to assess relationships with length of stay. Results: Higher PRECISE-HBR scores were associated with older age, female sex, hypertension, and chronic kidney disease. Major bleeding increased across score categories (7.7%, 19.4%, and 34.6%; p = 0.010) and total hospital stay was longer in the highest category (p = 0.033). PRECISE-HBR score showed weak positive correlations with intensive care unit stay (r = 0.270, p < 0.001), ward stay (r = 0.148, p = 0.044), and total hospitalization duration (r = 0.244, p = 0.001). Discrimination was moderate for major bleeding (AUC 0.748, 95% CI 0.662-0.824) and modest for prolonged hospitalization (AUC 0.615, 95% CI 0.532-0.694). Each one-point increase in PRECISE-HBR score was associated with major bleeding (OR 1.15, 95% CI 1.09-1.22; p < 0.001) and prolonged hospitalization (OR 1.06, 95% CI 1.02-1.11; p = 0.007), but not in-hospital mortality. Conclusion: Higher PRECISE-HBR scores were associated with major bleeding and longer hospitalization after TAVI. The score may aid bleeding-risk assessment and estimation of hospitalization burden, although prospective external validation is required.
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Saraçoğlu et al. (2026) conducted an observational in Severe aortic stenosis undergoing TAVI (n=184). PRECISE-HBR score vs. Lower PRECISE-HBR score was evaluated on Major bleeding (BARC type 3 or 5) per one-point increase in score (OR 1.15, 95% CI 1.09-1.22, p=<0.001). Each one-point increase in the PRECISE-HBR score was significantly associated with higher odds of major bleeding (OR 1.15) and prolonged hospitalization after transcatheter aortic valve implantation.
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