From mitochondria to arrhythmia: Rare phenotype of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes presenting with long QT type 3 pattern

Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like episodes (MELAS) is a rare, mitochondrial-inherited, multisystem disorder often presenting early in life with unexplained headaches, seizures, myopathy, neurologic deficits, early onset diabetes, and profound lactic acidosis1. The diverse clinical manifestations of mitochondrial disease reflect the role of mitochondria in cellular energy production and their ubiquitous presence throughout the body.