Key result
A 27-year-old female with MELAS syndrome developed an intracardiac thrombus leading to cerebral infarction, suggesting that cardiac involvement in MELAS may increase the risk of thromboembolism.
Case Report (n=1)
No
Highlights the importance of evaluating for intracardiac thrombus in patients with MELAS syndrome and cardiac involvement who present with stroke-like episodes.
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Screen for apical thrombus in MELAS stroke; leaves open need for routine cardiac imaging in mitochondrial disease.
Myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS) is a multisystem clinical syndrome manifested by mitochondrial myopathy, encephalopathy, lactic acidosis and recurrent stroke-like episodes. A 27-year-old female with MELAS syndrome presented with cerebral infarction. Echocardiography revealed a thrombus attached to the apex of the hypertrophied left ventricle, with decreased systolic function. The embolism of the intracardiac thrombus might have been the cause of stroke. There should be more consideration given to the increased possibility of intracardiac thrombus formation when a MELAS patient with cardiac involvement is encountered.
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Joo et al. (2013) conducted a case report in MELAS syndrome (n=1). MELAS syndrome with cardiac involvement was evaluated. A 27-year-old female with MELAS syndrome developed an intracardiac thrombus leading to cerebral infarction, suggesting that cardiac involvement in MELAS may increase the risk of thromboembolism.
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