Key result
Trillium govanianum extract tablets demonstrate concentration-dependent in vitro ACE inhibitory and antioxidant activity.
Why the study?
The potential antihypertensive effects of herbal tablets containing Trillium govanianum extract have not been established and require formulation and evaluation.
An optimized herbal tablet formulation of Trillium govanianum extract demonstrated promising in vitro ACE inhibitory and antioxidant activities, suggesting potential as a natural antihypertensive agent pending in vivo validation.
Preclinical tablet development warrants no practice change; leaves open clinical antihypertensive efficacy in humans.
The goal of the current study was to create and assess herbal tablets using rhizome extract from Trillium govanianum for possible antihypertensive effects. The Soxhlet extraction method was used to create the methanolic extract, which was then integrated into tablets using the wet granulation technique. For pre-compression and post-compression parameters, five formulations (F1–F5) were created and assessed. Formulation F3 was chosen as the optimal formulation based on the evaluation. The improved pills were then examined for antihypertensive potential using the angiotensin-converting enzyme (ACE) inhibitory assay and for in vitro antioxidant activity using DPPH and nitric oxide radical scavenging assays. The improved formulation showed concentration-dependent antioxidant and ACE inhibitory effects in addition to acceptable physicochemical characteristics. These results suggest that herbal pills containing Trillium govanianum have a promising antihypertensive potential and may be used as a natural treatment for hypertension. To determine their safety and therapeutic efficacy, more in vivo research is needed.
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Payal Dogra1*, Dr. Chinu Kumari2, Rahul Awasthi2, Dr. Abhishek Soni2 (2026) studied Hypertension. Trillium govanianum extract herbal tablets was evaluated on Angiotensin-converting enzyme (ACE) inhibitory effect and in vitro antioxidant activity. Herbal tablets containing Trillium govanianum extract demonstrated concentration-dependent in vitro antioxidant and angiotensin-converting enzyme inhibitory effects.
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