Key result
Basal septal thickening is linked to early hereditary transthyretin cardiac amyloidosis over 13-year follow-up.
Why the study?
Early echocardiographic manifestations of hereditary transthyretin cardiac amyloidosis before overt LV wall thickening are not well characterized.
Observational
Basal septal thickening may serve as an early echocardiographic manifestation of hereditary transthyretin cardiac amyloidosis, potentially preceding overt concentric left ventricular wall thickening.
Transthyretin cardiac amyloidosis (ATTR-CA) is increasingly recognized as a cause of heart failure1,2 owing to heightened disease awareness and advances in multimodality imaging.3 While echocardiography remains the cornerstone of initial screening, diagnostic suspicion is often based on the presence of overt concentric left ventricular (LV) wall thickening, typically in association with advanced diastolic dysfunction, abnormal myocardial strain, and impaired longitudinal function.4,5
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Kazzi et al. (2026) conducted an observational in Hereditary Transthyretin Cardiac Amyloidosis (ATTR-CA). Basal septal thickening was evaluated. Basal septal thickening was evaluated as a potential early echocardiographic manifestation of hereditary transthyretin cardiac amyloidosis over a 13-year follow-up period.
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