Key result
Anaphylaxis-related resuscitation and catecholamines trigger reversible Takotsubo cardiomyopathy in a 16-month-old infant.
Why the study?
Pediatric cases of Takotsubo cardiomyopathy, especially in infants and toddlers, are rare and underreported following anaphylaxis and resuscitation.
Case Report (n=1)
Highlights Takotsubo cardiomyopathy as a rare but important cause of transient myocardial dysfunction in infants following severe stress and catecholamine exposure such as in anaphylaxis.
Alerts clinicians to Takotsubo cardiomyopathy in pediatric anaphylaxis; leaves open its incidence and need for prospective data.
Takotsubo cardiomyopathy (TTC) is a reversible stress-induced myocardial syndrome characterized by transient left ventricular (LV) dysfunction in the absence of coronary artery disease. Pediatric cases are rare, especially in infants and toddlers. We report a 16-month-old female child who developed TTC following severe pneumonia complicated by antibiotic-induced anaphylaxis, cardiopulmonary arrest, and catecholamine exposure during resuscitation. Electrocardiography showed T-wave inversions, and echocardiography demonstrated transient mid and apical LV hypokinesia with preserved basal function. Cardiac troponin-I was markedly elevated. Serial echocardiography documented complete recovery of ventricular function. This case emphasizes the need to consider TTC in young children presenting with myocardial dysfunction following anaphylaxis and resuscitation and highlights the importance of early echocardiographic evaluation.
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Reddy et al. (2026) conducted a case report in Takotsubo cardiomyopathy following anaphylaxis (n=1). Antibiotic-induced anaphylaxis and catecholamine exposure was evaluated. A 16-month-old child developed transient Takotsubo cardiomyopathy following antibiotic-induced anaphylaxis and catecholamine exposure during resuscitation, with complete recovery.
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