Key result
Milrinone normalizes LVEF to 55% in a 6-year-old with post-traumatic Takotsubo cardiomyopathy.
Why the study?
Takotsubo cardiomyopathy is rare in children, and distinguishing it from myocardial contusion following physical trauma is clinically challenging due to overlapping features.
Case Report (n=1)
No
This case highlights the importance of early recognition of Takotsubo cardiomyopathy in pediatric trauma patients and the cautious use of inotropic agents like milrinone to avoid exacerbating catecholamine-induced myocardial stress.
TTC warrants consideration in pediatric trauma with LV dysfunction; leaves open reliable differentiation from myocardial contusion.
Takotsubo cardiomyopathy (TTC), also known as stress-induced cardiomyopathy, is a rare condition in children that causes acute, severe, but often reversible systolic dysfunction of the left ventricle. Physical trauma is a recognized trigger, although distinguishing TTC from myocardial contusion in pediatric trauma cases can be challenging due to overlapping clinical features. We present the case of a six-year-old boy involved in a high-impact motor vehicle collision. The patient initially presented with multiple traumatic injuries, including fractures of the skull, ribs, and right upper extremity, as well as pulmonary contusions. After initial stabilization in the pediatric intensive care unit (PICU), he developed hemodynamic instability six hours postoperatively, with elevated troponin levels suggesting myocardial contusion. Echocardiography later revealed severe left ventricular dysfunction with apical akinesia and basal hyperkinesis, hallmark findings of TTC. Inotropic support was switched from dobutamine to milrinone to avoid exacerbating catecholamine-induced myocardial stress. Over seven days, the patient's left ventricular function normalized, with an ejection fraction of 55%, and he was discharged on day 15 in stable condition. This case highlights the importance of early recognition of TTC in pediatric trauma patients, where echocardiography and cautious use of inotropic agents can ensure optimal outcomes.
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Zyani et al. (2024) conducted a case report in Post-traumatic Takotsubo Cardiomyopathy (n=1). Milrinone was evaluated on Left ventricular ejection fraction recovery. In a 6-year-old boy with post-traumatic Takotsubo cardiomyopathy, management with milrinone led to complete normalization of left ventricular function with an ejection fraction of 55% by day 7.
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