Key result
ICU-related Takotsubo cardiomyopathy carries ~20% in-hospital mortality, with survivors achieving left ventricular recovery.
Why the study?
Critically ill patients are particularly vulnerable to Takotsubo cardiomyopathy due to heightened catecholamine response, motivating a description of the clinical profile, ECG and echocardiographic findings, and short-term outcomes in ICU patients.
Case Report (n=5)
No
Answers are grounded in this paper and cite their sources.
This case series demonstrates that Takotsubo cardiomyopathy in critically ill ICU patients is frequently precipitated by severe physical stressors such as sepsis, surgery, or trauma, and while LV dysfunction is reversible in most survivors within weeks with supportive care, mortality remains a risk due to cardiogenic shock.
Objective: Takotsubo cardiomyopathy (TTC) is an acute, transient left ventricular (LV) dysfunction that mimics acute coronary syndrome.Critically ill patients are particularly vulnerable due to heightened catecholamine response.The aim of the study was to describe the clinical profile, electrocardiographic (ECG) and echocardiographic findings, and short-term outcomes of intensive care unit (ICU) patients diagnosed with Takotsubo cardiomyopathy.Case presentation: This case series includes 5 ICU patients diagnosed with Takotsubo Cardiomyopathy between July 2025 and October 2025.Clinical presentation, ECG, biomarkers, echocardiographic findings and outcomes were analysed.Mean age was 50.6 years; 3 out of 5 cases were female.Common triggers were physical stressors like major trauma, missed abortion with severe sepsis, major surgery for active and metastasized carcinoma rectum, severe sepsis with ards, mechanical ventilatory support with bronchoscopy for recurrent lower respiratory tract infections.All had transient LV dysfunction.Apical ballooning was the most common pattern.Average recovery time was 2 weeks.In-hospital mortality was 1 out of 5 cases.Conclusion: Takotsubo cardiomyopathy occurs in critically ill patients, often triggered by stress or sepsis, and carries favourable recovery potential with supportive management.
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Malani et al. (2025) conducted a case report in Takotsubo cardiomyopathy in critically ill intensive care unit patients (n=5). Physical or critical illness stressors (sepsis, trauma, surgery, bronchoscopy) was evaluated on In-hospital mortality and left ventricular ejection fraction recovery.
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