Key result
Early-onset dyslipidemia affects ~26% of adults in Northwest China, linked to standard cardiometabolic risk factors.
Why the study?
There is a lack of high-quality data on the prevalence and risk factors of early-onset dyslipidemia in Northwest China.
Cross-Sectional (n=3,559,141)
Yes
More than one-quarter of adults in Northwestern China suffer from early-onset dyslipidemia, emphasizing the need for robust lifestyle modifications and targeted lipid-lowering strategies among individuals with metabolic risk factors.
Background China has a large population, and the prevalence of dyslipidemia varies across regions. The prevalence of dyslipidemia is closely associated with the increasing burden of cardiovascular disease. Currently, there is a lack of high-quality data on early-onset dyslipidemia in Northwest China. This study aims to comprehensively assess the prevalence and risk factors of early-onset dyslipidemia among adults in this region, providing epidemiological evidence for disease prevention and health promotion. Methods This is a cross-sectional study based on the universal health check-up program conducted in northwestern China from January to December 2019. Adults (aged 18 to 65 years old) living in both rural and urban areas were included. Participants received a questionnaire survey, physical examination, and laboratory tests, including liver and kidney function, complete blood count, fasting blood glucose, and lipid profile. Result This study included a total of 3,559,141 participants (43.2% male and 56.8% female). The prevalence of early-onset dyslipidemia was 25.7%, with hypercholesterolemia accounting for 3.6%, hypertriglyceridemia for 10.6%, elevated low-density lipoprotein cholesterol for 2.7%, and reduced high-density lipoprotein cholesterol for 14.5%. Abnormalities in a single lipid parameter were observed in 20.5% of participants, while abnormalities in two, three, and four lipid parameters were observed in 4.6%, 0.6%, and 0.1% of participants, respectively. Male sex, age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity were all significant risk factors for early-onset dyslipidemia. Conclusion The age-standardized prevalence of early-onset dyslipidemia and its subtypes in Northwest China remains lower than the national level. Existing evidence consistently indicates that males, advancing age, diabetes, hypertension, smoking, alcohol consumption, and overweight/obesity are independent risk factors for early-onset dyslipidemia. Therefore, systematic screening should be initiated for this population (< 40 years old), with stratified management involving enhanced lifestyle interventions combined with evidence-based lipid-lowering medications.
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Liu et al. (2026) conducted a cross-sectional in Early-onset dyslipidemia (n=3,559,141). Demographic, clinical, and lifestyle risk factors (e.g., male sex, hypertension, diabetes, smoking, obesity) vs. Reference groups without corresponding risk factors was evaluated on Prevalence of early-onset dyslipidemia. The prevalence of early-onset dyslipidemia in Northwest China was 25.7%, with male sex, older age, diabetes, hypertension, smoking, alcohol use, and higher BMI identified as independent risk factors.
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