Key result
Retrograde non-coronary cusp ablation successfully eliminates para-Hisian accessory pathway while preserving normal AV conduction.
Why the study?
Para-Hisian accessory pathways are challenging to ablate due to their proximity to the AV conduction system and risk of iatrogenic AV block, with the non-coronary cusp emerging as an alternative target.
Does ablation from the non-coronary cusp safely eliminate para-Hisian accessory pathways without causing atrioventricular block in patients with failed right-sided approaches?
Case Report (n=1)
Does ablation from the non-coronary cusp safely eliminate para-Hisian accessory pathways without causing atrioventricular block in patients with failed right-sided approaches?
The non-coronary cusp represents a safe and effective alternative target for ablation of para-Hisian accessory pathways when conventional right-sided ablation fails or poses a high risk of AV block.
May support non-coronary cusp ablation after failed right-sided attempts; hypothesis-generating and requires prospective studies before wider use.
Para-Hisian accessory pathways (PHAPs) remain among the most challenging substrates for catheter ablation because of their close anatomical relationship to the atrioventricular (AV) conduction system and the consequent risk of iatrogenic AV block. The non-coronary cusp (NCC) has emerged as a valuable alternative when right-sided ablation is ineffective or associated with an unacceptable risk of injury to the His bundle. We report the case of a 23-year-old man who presented with pre-excited atrial fibrillation. Electrophysiological study localized an anteroseptal/para-Hisian accessory pathway. Electroanatomical mapping identified the earliest ventricular activation at the para-Hisian region; however, multiple irrigated radiofrequency applications from the right atrial septum failed to eliminate pre-excitation because of the close proximity to the His bundle. A retrograde aortic approach to the NCC was subsequently undertaken using three-dimensional electroanatomical mapping integrated with intracardiac echocardiography. Mapping within the NCC demonstrated an accessory pathway potential with atrioventricular fusion and ventricular activation preceding delta-wave onset by 20 ms. Radiofrequency delivery at this site resulted in elimination of pre-excitation within 3 s while preserving normal AV conduction. No recurrence of pre-excitation or impairment of AV nodal conduction was observed during post-ablation assessment. This case supports the NCC as a safe and effective alternative target when conventional right-sided ablation is unsuccessful or poses a significant risk of AV conduction injury.
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Marins et al. (2026) conducted a case report in Para-Hisian accessory pathway (PHAP) (n=1). Radiofrequency catheter ablation from the non-coronary cusp was evaluated on Elimination of pre-excitation and preservation of atrioventricular conduction. A retrograde aortic approach to the non-coronary cusp resulted in successful elimination of a para-Hisian accessory pathway within 3 seconds while preserving normal atrioventricular conduction.
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