Key result
Transarterial catheter ablation of subclavian ansae targets central sympathetic denervation in swine.
Why the study?
Sympathetic hyperactivation contributes to cardiac arrhythmias, and current treatments like stellate block or ganglionectomy are either temporary or invasive, necessitating alternative approaches.
SA stimulation confirms sympathetic signaling; hypothesis-generating for arrhythmia neuromodulation, needs prospective trials.
Sympathetic hyperactivation plays a key role in the initiation and perpetuation of cardiac arrhythmias. The subclavian ansae (SA) contains sympathetic nerve fibers that convey efferent signaling from the stellate ganglia to the cardiovascular (CV) system. Stimulation of the SA increases heart rate (HR) and arterial blood pressure (ABP), confirming sympathetic activation. Stellate block and surgical stellate ganglionectomy suppress ventricular arrhythmias; however, they are either temporary or invasive.
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Piccini et al. (2026) studied Cardiac arrhythmias. Transarterial catheter ablation of the subclavian ansae was evaluated. Transarterial catheter ablation of the subclavian ansae was evaluated in swine, but the provided abstract contains no clinical outcomes or quantitative results.
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