Key result
Carney complex cardiac myxomas can rapidly progress despite screening, causing recurrent cardioembolic strokes requiring urgent excision.
Why the study?
Familial cardiac myxomas can progress rapidly and unpredictably despite negative screening, posing a risk of recurrent cardioembolic stroke.
Familial cardiac myxomas in Carney complex can develop rapidly and unpredictably despite prior negative screening, necessitating high vigilance and prompt surgical intervention when identified.
Prompt excision may avert embolization in symptomatic pediatric Carney complex; leaves open optimal surveillance protocols for familial myxomas.
A 14-year-old girl with biopsy-proven extracardiac myxomas presented with recurrent cardioembolic stroke due to a rapidly developing giant left atrial myxoma. A pathogenic PRKAR1A variant and maternal history confirmed familial Carney complex. Urgent surgical excision prevented further embolization, emphasizing the aggressive and unpredictable nature of familial cardiac myxomas.
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Dsouza et al. (2026) studied this question. Familial cardiac myxomas in Carney complex can exhibit aggressive and rapid progression despite negative screening, causing recurrent cardioembolic strokes that require urgent excision.
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