Key result
Flecainide may increase capture thresholds, but clinical relevance with contemporary steroid-eluting leads remains unclear.
Why the study?
Flecainide may increase myocardial capture thresholds, but its clinical relevance with contemporary steroid-eluting leads is unknown.
Design
Prospective multicenter longitudinal study
Flecainide associates with modest early capture threshold rises without device malfunction; leaves open whether age-stratified monitoring is needed.
Flecainide is a class IC antiarrhythmic drug widely used for rhythm control in patients without structural heart disease.1,2 Previous reports suggest that flecainide may increase myocardial capture thresholds.3 Whether this effect remains clinically relevant with contemporary steroid-eluting leads4 is unknown.
No takes yet. Share an insight, caveat, or question.
Santoro et al. (2026) studied this question. Flecainide may increase myocardial capture thresholds, though its clinical relevance in patients with contemporary steroid-eluting leads remains unknown.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: