Key result
Mechanical thrombectomy achieves ~80% home discharge in real-world large-vessel occlusion stroke.
Why the study?
Significant global variation exists in access to treatments and management practices for AIS due to LVO, potentially contributing to outcome variability beyond current guidelines.
Observational (n=282)
Yes
There is significant global variation in access to treatments and specialized teams for acute ischemic stroke due to large-vessel occlusion, which may impact patient outcomes.
Low thrombolysis rates in observational stroke data signal possible care gaps; leaves open questions on barriers and solutions.
Acute ischemic stroke (AIS) is a leading cause of death and disability worldwide.Thrombolysis, mechanical thrombectomy (MT) and surgical decompression are gold standard treatments for AIS due to large-vessel occlusion (LVO), yet access varies across regions.The Global Stroke Outcomes study provides an international overview of patient characteristics, care pathways, and outcomes for AIS due to LVO.Methods: This prospective, multicenter, international observational study recruited sites globally through collaborations including Mission:Brain, Mission Thrombectomy, and regional networks.Centers completed site questionnaires and prospectively collected patient data using standardized case report forms over 30 days.All patients presenting with AIS due to LVO were included irrespective of treatment.Outcomes were discharge status, 30-day mortality, and treatments.Results: Data from 21 sites and 282 patients were analyzed.Most sites were urban (90.5%) and tertiary centers (90.5%).All sites had access to internal medicine, emergency medicine, intensive care, and neurosurgery; only 61.9% had neurointerventional radiology or angiography suites.MT specialties varied.Of 54 MT-eligible patients, 79.7% underwent the procedure.8.7% received thrombolysis, and 2.0% underwent decompressive craniectomy.Variation occurred in imaging and antiplatelet use.At discharge, 80% returned home where the median Glasgow Coma Scale (GCS) before discharge was 15.Conclusions: Significant global variation exists in access to AIS treatments including MT, specialized teams, and management practices for AIS due to LVO.These differences may contribute to outcome variability beyond current MT guidelines
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Nguyen et al. (2026) conducted an observational in Acute ischemic stroke due to large-vessel occlusion (n=282). Acute ischemic stroke treatments (including mechanical thrombectomy) was evaluated on Discharge status, 30-day mortality, and treatments. Among 282 patients with acute ischemic stroke due to large-vessel occlusion across 21 global sites, 79.7% of eligible patients underwent mechanical thrombectomy and 80% returned home at discharge.
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