Key result
The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio was not independently associated with isolated nocturnal hypertension after adjustment for cardiometabolic risk factors.
Why the study?
The relationship between isolated nocturnal hypertension and insulin resistance remains uncertain.
Is isolated nocturnal hypertension independently associated with an elevated TG/HDL-C ratio (a marker of insulin resistance) in patients undergoing ambulatory blood pressure monitoring?
Cross-Sectional (n=1,623)
Is isolated nocturnal hypertension independently associated with an elevated TG/HDL-C ratio (a marker of insulin resistance) in patients undergoing ambulatory blood pressure monitoring?
Insulin resistance, as estimated by the TG/HDL-C ratio, is not an independent determinant of isolated nocturnal hypertension but rather reflects its accompanying adverse metabolic profile.
Isolated nocturnal hypertension is associated with increased cardiovascular risk, but its relationship with insulin resistance remains uncertain. In this study of 1623 patients undergoing ambulatory blood pressure monitoring, the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio was higher in patients with isolated nocturnal hypertension than in normotensive individuals; however, this association was no longer significant after adjustment for cardiometabolic risk factors. These findings suggest that insulin resistance reflects the adverse metabolic profile accompanying isolated nocturnal hypertension rather than an independent determinant of this phenotype.
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Minetto et al. (2026) conducted a cross-sectional in Isolated nocturnal hypertension (n=1,623). Triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio vs. Normotensive individuals was evaluated on Association with isolated nocturnal hypertension. The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio was not independently associated with isolated nocturnal hypertension after adjustment for cardiometabolic risk factors.
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