Key result
Hypertension and being overweight demonstrated additive effects in increasing insulinemia, while being overweight was associated with a significantly lower nocturnal fall in blood pressure.
Why the study?
Are hypertension and overweight status associated with hyperinsulinemia and altered ambulatory blood pressure patterns in men?
Population
31 uncomplicated hypertensive men not receiving antihypertensive treatment and 10 lean normotensive controls.
Design
Cross-sectional
Authors
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Supports metabolic-BP links in overweight hypertension; leaves open causality and need for prospective trials before practice change.
Observational (n=41)
Are hypertension and overweight status associated with hyperinsulinemia and altered ambulatory blood pressure patterns in men?
Hypertension and overweight status additively increase insulin resistance, with overweight status linked to a non-dipping nocturnal blood pressure pattern.
Feldstein et al. (1998) conducted an observational in Hypertension and insulin resistance (n=41). High and middle body mass index (overweight) vs. Low body mass index (lean) and normotensive controls was evaluated on Plasma glucose and insulin levels during a 2 h oral glucose-tolerance test, and 24 h ambulatory blood pressure. Hypertension and being overweight demonstrated additive effects in increasing insulinemia, while being overweight was associated with a significantly lower nocturnal fall in blood pressure.
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