Key result
Targeted PCR detects no enterovirus in chronic histiocytic intervillositis, arguing against occult infection.
The absence of enterovirus in placental tissues with chronic histiocytic intervillositis supports the consensus that the condition is immune-mediated rather than driven by an occult enterovirus infection.
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Enterovirus unlikely in CHI; supports immune-mediated consensus while leaving other triggers open for study.
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Cornish et al. (2026) conducted a letter in Chronic histiocytic intervillositis (CHI) (n=12). Enterovirus infection was evaluated on Detection of enterovirus using targeted real-time PCR. Targeted real-time PCR detected no enterovirus in 14 placental samples from 12 women with chronic histiocytic intervillositis, indicating occult enterovirus infection is unlikely to cause CHI.
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