Key result
Severe valvular disease affects ~80% of congested HFpEF patients, but functional regurgitation often regresses post-stabilization.
Reveals that dynamic functional valvular regurgitation drives acute decompensation in heart failure with preserved ejection fraction, suggesting timing of assessment influences diagnosis.
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Maria Giulia Bellicini (2026) conducted a letter in Acute heart failure with preserved ejection fraction (HFpEF) (n=770). Dynamic severe functional valvular regurgitation vs. Post-stabilization status was evaluated. Severe valvular disease was the predominant structural substrate during acute congestion in nearly 80% of HFpEF patients, but functional regurgitation frequently regressed following stabilization.
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