Key result
VA-ECLS plus heparin successfully restores hemodynamic stability in massive pulmonary embolism during pregnancy.
Why the study?
Massive pulmonary embolism is a leading cause of death during pregnancy and there is no consensus regarding its treatment.
May support ECLS-heparin rescue in refractory pregnant PE shock; leaves open need for prospective validation before wider adoption.
Massive pulmonary embolism is a leading cause of death during pregnancy. While the prevention of thromboembolic disease during the peripartum period is codified, there is no consensus regarding its treatment. We report two cases of pregnant women who had massive pulmonary embolisms (PE) and shock treated with veno-arterial extracorporeal life support (ECLS) and heparin therapy.Haemodynamic and oxygenation parameters were rapidly restored. The patients completely recovered and the pregnancies continued. The patients did not develop pulmonary hypertension. ECLS can be considered as a successful treatment option of massive pulmonary embolism during pregnancy.
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Bataillard et al. (2015) conducted a review in Massive pulmonary embolism during pregnancy (n=2). Veno-arterial extracorporeal life support (ECLS) and heparin therapy was evaluated on Haemodynamic and oxygenation recovery, and continuation of pregnancy. Veno-arterial extracorporeal life support combined with heparin therapy successfully restored hemodynamic stability and oxygenation in two pregnant women with massive pulmonary embolism, allowing for complete recovery and continuation of pregnancy.
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