We report the combined experimental and computational investigation of systems involving carbonyl-containing bicyclobutonium cation intermediates generated by I(III)-mediated oxidative Umpolung or acylation of cyclobutenes. The regio- and diastereoselectivity of their nucleophilic capture relies on the in situ formation of “locked” oxocarbenium intermediates and “unlocked” cyclobutyl cations.
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Xiao et al. (2026) studied this question.
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