Key result
DHA supplementation significantly reduces blood pressure and heart rate compared to placebo in middle-aged men.
Why the study?
The effects of daily docosahexaenoic acid supplementation on coronary heart disease risk factors in hypertensive and hypercholesterolemic men were investigated.
RCT (n=38)
Double-blind
Randomized
No
Answers are grounded in this paper and cite their sources.
To investigate the effects of daily supplementation with docosahexaenoic acid (DHA) on coronary heart disease risks in 38 middle-aged men with hypertension and/or hypercholesterolemia in Scotland, a five-week double-blind placebo-controlled dietary supplementation with either 2 g of DHA or active placebo (1 g of olive oil) was conducted. Percent composition of DHA in plasma phospholipids increased significantly in DHA group. Systolic and diastolic blood pressure and heart rate decreased significantly in DHA group, but not in placebo group. High-density lipoprotein cholesterol (HDL-C) increased significantly, and total cholesterol (TC)/HDL-C and non-HDL-C/HDL-C ratios decreased significantly in both groups. There was no change in TC and non-HDL-C. We conclude that 2 g/day of DHA supplementation reduced coronary heart disease risk factor level improving blood pressure, heart rate, and lipid profiles in hypertensive, hypercholesterolemic Scottish men who do not eat fish on a regular basis.
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Sagara et al. (2011) conducted an RCT in Hypertension and hypercholesterolemia (n=38). Docosahexaenoic acid (DHA) vs. Olive oil (1 g/day) was evaluated on Change in systolic blood pressure from baseline (p=0.19). Daily supplementation with 2 g of DHA for 5 weeks reduced systolic blood pressure by 8.3 mmHg from baseline, but this reduction was not significantly different from the olive oil placebo group (P = 0.19).
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