Treatment Discontinuation of Blood Pressure–Lowering Drugs

“Potential differences in tolerability of these drug classes overall should not override selecting specific antihypertensive medications for patients for whom the benefits are well established, such as ARBs or ACE inhibitors for patients with diabetes and albuminuria or heart failure with reduced ejection fraction.”

“Fear of adverse events remains a major reason for undertreatment of high blood pressure, the leading modifiable risk factor for death and cardiovascular disease worldwide. For years, we have assumed that more blood pressure-lowering treatment equates to worse tolerability, and hence most patients are started and remain on single drug monotherapy.”