Key result
Curcumin attenuates sepsis-induced cardiomyopathy in experimental models by downregulating TLR1 to reduce cardiomyocyte apoptosis.
Why the study?
Sepsis-induced cardiomyopathy is a major cause of death among sepsis patients with elusive pathophysiology, requiring molecular insights for new therapies.
Curcumin may merit translational studies in sepsis-induced cardiomyopathy; hypothesis-generating for TLR1-targeted therapies pending human trials.
The noteworthy progress over the last decade in molecular technologies and bioinformatic tools has led to the generation and integration of significant amounts of Big data, including DNA, RNA, protein and metabolite levels of a wide range of tissue samples and patients.These have improved our knowledge of health and disease and consequently enabled the leverage of precision medicine for several diseases.Worldwide, sepsis is an ongoing challenge for physicians and health-care administrators due to its high incidence, mortality and its huge burden on public health resources in developed countries.It is the leading cause of intensive care unit related deaths. 1 Sepsis-induced cardiomyopathy (SICM) or sepsis-induced myocardial dysfunction (SIMD) is a form of transient cardiac
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Ilda Patrícia Ribeiro (2023) conducted an editorial in Sepsis-induced cardiomyopathy. Curcumin was evaluated. Curcumin demonstrates potential therapeutic effects in sepsis-induced cardiomyopathy by downregulating TLR1 to inhibit cardiomyocyte apoptosis in experimental models.
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