Endocannabinoids contribute to sex-related processes, including puberty. In 1,159 adolescents, females showed significantly lower concentrations than males across five endocannabinoids (AEA, 2-AG, PEA, OEA, and 2-OG). Sex-by-puberty interactions were significant for AEA, PEA, and OEA. Exploratory analyses revealed sex-specific associations between endocannabinoids and self-reported pain, stress, internalizing, and attentional problems.
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Evanski et al. (2026) studied this question.
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