Key result
Deprescribing CV medications in multimorbid older adults reduces medication burden and adverse drug reactions.
Why the study?
Deprescribing is rarely addressed in current clinical practice guidelines despite its importance for older adults with cardiovascular disease and multimorbidity to prevent medication-related complications and improve outcomes.
Does deprescribing cardiovascular medications improve outcomes and reduce medication burden in older adults with cardiovascular disease and multimorbidity?
Does deprescribing cardiovascular medications improve outcomes and reduce medication burden in older adults with cardiovascular disease and multimorbidity?
Deprescribing is a critical, patient-centered process for reducing unnecessary medication burden and adverse drug events in older adults with cardiovascular disease.
Deprescribing, an integral component of a continuum of good prescribing practices, is the process of medication withdrawal or dose reduction to correct or prevent medication-related complications, improve outcomes, and reduce costs. Deprescribing is particularly applicable to the commonly encountered multimorbid older adult with cardiovascular disease and concomitant geriatric conditions such as polypharmacy, frailty, and cognitive dysfunction–a combination rarely addressed in current clinical practice guidelines. Triggers to deprescribe include present or expected adverse drug reactions, unnecessary polypharmacy, and the need to align medications with goals of care when life expectancy is reduced. Using a framework to deprescribe, this review addresses the rationale, evidence, and strategies for deprescribing cardiovascular and some noncardiovascular medications.
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Krishnaswami et al. (2019) conducted a review in Cardiovascular disease and multimorbidity. Deprescribing was evaluated. Deprescribing cardiovascular medications in older adults with multimorbidity can reduce medication burden, minimize adverse drug reactions, and improve quality of life.
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