Key result
Autophagy exerts dual protective and detrimental roles in myocardial hypertrophy depending on activation and stage.
Why the study?
Autophagy has dual effects in myocardial hypertrophy, with both protective and harmful roles reported, creating uncertainty about its overall impact.
Answers are grounded in this paper and cite their sources.
Autophagy modulation in hypertrophy warrants caution pending context; leaves open stage- and pathway-specific targets for trials.
Autophagy played a crucial role for survival when cells were suffering from nutrient deprivation, as autophagy could engulf and degenerate macromolecules to provide new nutrients and energy. Autophagy also plays an essential role in maintaining cellular homeostasis, which was activated in response to the cellular stresses in hypertensive heart disease. Interestingly, many studies had proven that the baseline and up-regulation of autophagy played a beneficial role in myocardial hypertrophy while other studies found that up-regulated autophagy was associated with myopathies. In this review, we showed the signalling pathways which were involved in myocardial hypertrophy. Besides, we talked about the protective as well as harmful effects of autophagy in myocardial hypertrophy. Finally, we proposed the possible reasons of dual effects of autophagy in hypertrophy, including the degree of the activation, the stage of the disease and the signalling pathways responsible for the activation of autophagy, etc.
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Li et al. (2015) conducted a review in Myocardial hypertrophy. Autophagy was evaluated. Autophagy exerts both protective and harmful effects in myocardial hypertrophy, which may depend on the degree of activation, disease stage, and responsible signaling pathways.
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