Key result
Cardiac surgery is associated with ~2-fold higher median survival in cervical cancer cardiac metastasis.
Why the study?
Malignant pericardial effusion secondary to cervical cancer is uncommon and its clinical management and prognosis are not well characterized.
Systematic Review (n=87)
Absolute Event Rate: 5% vs 2.5%
BACKGROUND: Antemortem discovery of a malignant pericardial effusion secondary to cervical cancer is uncommon and management should focus on symptom control. CASE: A patient was diagnosed with widely metastatic cervical cancer following a simple hysterectomy for presumed benign etiology. Sixteen months later, she was diagnosed with pericardial tumor involvement and a malignant pericardial effusion resulting in severe dyspnea. The patient underwent a pericardial window procedure that temporarily alleviated her symptoms. She again developed symptoms 2 weeks following the procedure and ultimately elected supportive care. CONCLUSION: Malignant pericardial effusion is a challenging clinical scenario. Although multiple treatment options exist, prognosis is poor and usually limited.
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Ore et al. (2013) conducted a systematic review in Cardiac metastasis from cervical cancer (n=87). Cardiac surgery vs. No cardiac surgery was evaluated on Median survival time after diagnosis of cardiac metastasis. In patients with cardiac metastasis from cervical cancer, median survival was 5 months among those who underwent cardiac surgery compared to 2.5 months in those who did not, though overall prognosis remained extremely poor.
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