Vicinal oxygenated scaffolds are prevalent in natural products and pharmaceuticals, yet a general method for divergent access to vicinal oxygenated motifs is still a synthetic challenge. We report a visible-light photoredox esterification−peroxidation of alkenes with carboxylic acids and tert-butyl hydroperoxide. Independent conversion of the peroxy and ester groups gives diverse vicinal oxygenated skeletons. This protocol establishes a unified platform for the divergent construction of vicinal oxygenated scaffolds and concise synthesis of phenylpropanoid natural products.
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Pan et al. (2026) studied this question.
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