This process demonstrates peroxyesterification of arylcyclopropanes using carboxylic acids and photocatalysts, indicating a metal-free method with functional-tolerance.
Organic peroxides constitute a privileged family of O–O-containing compounds that serve as indispensable reagents or synthetic intermediates in industrial processes, pharmaceutical manufacturing, and polymer sciences. Herein, we disclose a photocatalytic ring-opening transformation of arylcyclopropanes with carboxylic acids and tert-butyl hydroperoxide, which enables the facile construction of structurally diverse 1,3-peroxyesterification products. This protocol proceeds under exceptionally mild, metal-free conditions with exquisite site-selectivity and broad functional-group tolerance. Besides, late-stage functionalization of bioactive molecules and downstream transformations are also performed.
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Pan et al. (2025) studied this question.
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