The Mammogram That Cried Wolfe

That mammographic density is an important risk factor for breast cancer was first recognized by Wolfe in the 1970s. His pioneering observation has since been confirmed in more than 42 studies, the vast majority of which have shown an association between increased mammographic density and the risk of breast cancer.1 Women in the highest quartile of mammographic density have a risk of breast cancer that is approximately four to six times as high as that among women of similar age who are in the lowest quartile. Only two other factors increase the risk of breast cancer more than mammographic density: . . .