New Concepts in Steroid Glaucoma

Purpose of Review In this article, we discuss the pathophysiology underlying intraocular pressure elevation associated with corticosteroid use as well as targeted therapies for treatment. Recent Findings Several signaling pathways at the level of the trabecular meshwork are altered by steroid exposure. A pre-existing diagnosis of glaucoma is the best-established risk factor for development of steroid-associated ocular hypertension. Topical, local, and systemic steroids have all been associated with ocular hypertension. Summary Current management is directed at steroid-sparing alternatives to treatment, steroid cessation, IOP-lowering medications, and interventional lasers and surgery.