Voltage-Gated Potassium Channel/LGI1 Antibody–Associated Encephalopathy May Cause Brief Psychotic Disorder

Article AbstractLetter to the Editor Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text. Voltage-gated potassium channel (VGKC) antibody-associated encephalopathy has been identified as a potentially immunotherapy-responsive form of limbic encephalitis. A recent study showed that the target antigen in this condition is in fact LGI1, a secreted neural protein that functions as a ligand for 2 epilepsy-related proteins, ADAM22 and ADAM23. Limbic encephalitis is typically a paraneoplastic syndrome with a poor prognosis.