Changes in the Concentrations of Calcium and Phosphorus During Modeling of Periodontal Tissue Disease and Its Correction

Background. Periodontitis, the leading cause of tooth loss in adults, is a common inflammatory-dystrophic disorder. As periodontitis occurs due to inflammation in the marginal gingiva caused by harmful bacteria, effective pharmacological intervention is essential. Aim: to investigate changes in the concentra-tions of calcium and phosphorus in the blood serum and periodontal tissue homogenate of rats using the model of experimental periodontitis, and to focus on the effects of substances with antioxidant and anti-inflammatory properties. Materials and Methods. Various natural substances were used in the treatments. "Vitamin C," "Rutin," and "Ascorutin" were administered intragastrically, while "Salviae tincture" was applied locally. The experiment involved 90 adult white rats divided into nine groups, with ten animals in each group, and measurements of calcium and phosphorus levels were taken on the 1st, 8th, and 15th days. Results and Discussion. It was found that the combined use of the conventional medicines "Ascorutin" and "Salviae tincture" was the most effective option for restoring calcium and phosphorus levels in both blood serum and periodontal tissue homogenate in experimental animals (p<0.05). The analyses of trends that characterize changes in calcium and phosphorus concentrations in blood serum and periodontal tissue homogenate demonstrate the synergistic effect of such a combination. The separate use of "Vitamin C," "Rutin," and "Sal-viae tincture" did not consistently lead to effective restoration of calcium and phosphorus levels in the blood serum and periodontal tissue homogenate. Regarding the effectiveness of treatment, "Ascorutin" occupied an average position. Conclusion and future perspectives. The combinative treatment with "Ascorutin" and "Salviae tincture" was the most effective approach for restoring the concentrations of calcium and phospho-rus in both blood serum and periodontal tissue homogenate in experimental rats. To broaden understanding of the effects of combining "Ascorutin" and "Salviae tincture" in treating experimental periodontitis, it is ad-vised to study how they influence enzyme activities, especially those involved in the body's antioxidant de-fense system.