Key result
Severe coronary occlusion of ≥70% is linked to significantly higher GGT levels in CHD.
Why the study?
Gamma Glutamyl Transferase (GGT) is a prognostic marker in coronary artery disease, but its relationship with severity of coronary occlusion was unclear.
Cross-Sectional (n=60)
No
Absolute Event Rate: 34.16% vs 21.33%
p-value: p=0.003
GGT should not yet inform occlusion assessment in CHD; extends mortality and calcification links but remains hypothesis-generating.
Background: Coronary heart disease (CHD) is a cumulation of plaque in the heart arteries that can cause heart attacks. CHD is one of the main and rst causes of death in developed and developing countries, including Indonesia. It is estimated that throughout the world, CHD in 2020 became the rst most frequent killer of 36% of all deaths, twice as high as cancer deaths. Currently Gamma Glutamyl Transferase (GGT) is a prognostic marker of death and reinfarction in patients with patients Coronary Artery Disease (CAD) and there is a relationship of GGT with the prognosis of CAD patients undergoing angiography. Methods: The study was conducted by cross sectional method. The study subjects were 60 male and female CHD patients who were treated and treated at the hospital in the Department of Cardiology FK-USU / H. Adam Malik Hospital Medan, which was enforced by history, physical examination, angiography and laboratory and underwent coronary angiography. GGT examination uses Architect c8000. Results: A total of 60 CHD patients in this study found that GGT values were greater in the ≥70% group compared with occlusions <70% with p = 0.003. Conclusions: This study showed a signicant difference in the values of GGT with occlusion ≥70% and <70% occlusion.
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Siahaan et al. (2020) conducted a cross-sectional in Coronary Heart Disease (n=60). Coronary artery occlusion ≥70% vs. Coronary artery occlusion <70% was evaluated on Gamma-glutamyl transferase (GGT) levels (p=0.003). Coronary heart disease patients with ≥70% occlusion had significantly higher gamma-glutamyl transferase levels compared to those with <70% occlusion (34.16 vs 21.33, p=0.003).
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