Key result
Intravenous isoproterenol suppresses recurrent VF and normalizes ST-segment elevation in Brugada syndrome.
Why the study?
The pathophysiological mechanism of Brugada syndrome and effective prevention of recurrent ventricular fibrillation remain unclear.
Case Report (n=1)
May support isoproterenol in refractory Brugada VF; hypothesis-generating and requires prospective validation before practice change.
TANAKA, H., et al.: Successful Prevention of Recurrent Ventricular Fibrillation by Intravenous Isoproterenol in a Patient with Brugada Syndrome. Intravenous administration of isoproterenol restored the ST‐segment configuration to nearly normal in the right precordial leads and completely prevented spontaneous VF attacks in a patient with Brugada syndrome. The formation of a Brugada‐type ECG has been attributed to the transmural dispersion of repolarization of the right ventricular epicardium and related to modulation of the autonomic nervous system. Our case may provide clues to the pathophysiological mechanism of this syndrome.
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Tanaka et al. (2001) conducted a case report in Brugada Syndrome (n=1). Intravenous isoproterenol was evaluated on Spontaneous ventricular fibrillation attacks and ST-segment configuration. Intravenous isoproterenol completely prevented spontaneous ventricular fibrillation attacks and nearly normalized the ST-segment in a patient with Brugada syndrome.
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