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A recent publication by Xu et al. suggests that Gi activation following 5-HT2AR stimulation differentiates hallucinogenic from nonhallucinogenic agonists. Here, we reanalyze the author’s source data to demonstrate that Gi activation is less predictive of hallucinogenic potential than canonical effectors of 5-HT2AR signaling.
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Hatzipantelis et al. (2026) studied this question.
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