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Reminiscent of the organs from which they arise, most cancers are composed of a heterogenous population of cells with marked differences in their proliferative potential, as well as the ability to reconstitute the tumor upon transplantation. Cancer stem cells are a minor population of tumor cells that possess the stem cell property of self-renewal. In addition, dysregulation of stem cell self-renewal is a likely requirement for the development of cancer. This new model for cancer will have significant ramifications for the way we study and treat cancer.
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Michael F. Clarke (2005) studied this question.
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