Key result
Shorter anticoagulant treatment duration links to progressively worse INR control, with up to ~41% out of range.
Why the study?
The quality of therapeutic control of oral anticoagulant therapy needs to be assessed and improved.
Observational (n=384)
Answers are grounded in this paper and cite their sources.
Suboptimal early-phase control may warrant intensified monitoring; leaves open targeted trials on duration-specific stabilization strategies.
Three hundred and eighty-four patients were studied for up to 1 year while on continuous oral anticoagulant therapy and the quality of control of therapy was assessed. Two hundred and thirty-five patients were on continuous therapy throughout the year (long-term group), 73 were treated for a period between 3 and 12 months (intermediate group) and 76 were treated for less than 3 months (short-term group). The therapeutic objective was to achieve and maintain British Ratio (BR) between 2.0 and 4.0. Nineteen percent of the results in the long-term group, 26.6% in the intermediate group and 41.1% in the short-term group fell outside this range. Among the long-term group only 25.1% and in the intermediate group 12.3% had all their results within the control range. It is concluded that the quality of therapeutic control of oral anticoagulant therapy needs to be improved.
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Majumdar et al. (1985) conducted an observational in Patients requiring oral anticoagulant therapy (n=384). Oral anticoagulant therapy was evaluated on British Ratio (BR) outside target therapeutic range (2.0 to 4.0). Oral anticoagulant therapy exhibited suboptimal control, with 19.0%, 26.6%, and 41.1% of results falling outside the target range in long-term, intermediate, and short-term groups, respectively.
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