"Association between Triglyceride Glucose Index and Arterial Stiffness in the Japanese Population: A Secondary Analysis of Cross-Sectional Study"

The trigly cerise glucose (TyG) index has been regard edams a reliable alternative biomarker of insulin resistance (IR).However, there are limited studies that have been carried out regarding the association between the TyG index and arterial stiffness.Therefore, the main objective of this research was to explore the correlation between the TyG index and arterial stiffness.This cross-sectional study recruited 912 Japanese whose age ranged from 24 to 84 years from a health checkup project.all subjects were divided into three groups.Multivariate linear regression demonstrated that the TyG index exhibited an independent positive association with baPWV (β0.34, 95%confidence interval [CI]0.08-0.59).Consistently, in the multivariable logistic regression, each unit increase in the TyG index increased the odds of having a higher prevalence of elevated arterial stiffness by 65% (OR 1.65, 95%CI1.08-2.54).According to the restricted cubic spline, the correlation between baPWV and TyG index was linear and did not find a threshold or saturation effect.Subgroup analyses revealed that the relationship between the TyG index and baPWV stably existed in different subgroups after adjusting covariates.In Conclusion, The TyG index is independently associated with arterial stiffness.