Key result
Higher TyG-BMI is linked to increased arterial stiffness, with risk rising sharply above ~175.
Why the study?
The TyG-BMI has emerged as a marker of insulin resistance, but its relationship with arterial stiffness needed investigation.
Is higher triglyceride glucose-body mass index (TyG-BMI) associated with increased arterial stiffness in adults?
Cross-Sectional (n=18,312)
No
Is higher triglyceride glucose-body mass index (TyG-BMI) associated with increased arterial stiffness in adults?
The TyG-BMI index is independently and positively associated with arterial stiffness, suggesting it may serve as a cost-effective surrogate marker for identifying high-risk individuals.
TyG-BMI may aid identification of adults at higher arterial stiffness risk; hypothesis-generating and requires prospective validation before clinical adoption.
The triglyceride glucose-body mass index (TyG-BMI) has emerged as a unique indicator of insulin resistance (IR). This study aimed to investigate the relationship between the TyG-BMI and arterial stiffness among 18,312 participants from Hebei General Hospital in China. The TyG-BMI was calculated based on serum triglycerides, fasting plasma glucose, and BMI, while arterial stiffness was estimated using the estimated pulse wave velocity (ePWV) derived from age and mean blood pressure. Multivariate regression analysis revealed that ePWV levels were significantly higher in the two highest TyG-BMI quartiles (Q3 and Q4) compared with the lowest quartile (Q1). Subgroup analysis demonstrated a consistent positive link between the TyG-BMI index and arterial stiffness (all P-interaction >0.05). Furthermore, ROC curve analysis and non-linear testing indicated that the risk of arterial stiffness remained relatively stable until the TyG-BMI reached approximately 175, after which it rose sharply (P for non-linearity <0.001). These findings suggest that the TyG-BMI index is independently and positively associated with arterial stiffness, serving as a reliable and cost-effective surrogate marker for identifying individuals at high risk in clinical settings.
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Li et al. (2026) conducted a cross-sectional in Arterial stiffness (n=18,312). Triglyceride glucose-body mass index (TyG-BMI) vs. Lowest TyG-BMI quartile (Q1) was evaluated on Arterial stiffness estimated using estimated pulse wave velocity (ePWV) (p=<0.001). The triglyceride glucose-body mass index was independently and positively associated with arterial stiffness, with the risk rising sharply after the index reached approximately 175 (P<0.001).
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