Key result
Multi-valvular endocarditis linked to higher heart failure rates vs uni-valvular disease, affecting ~64%.
Why the study?
The incidence and clinical features of multi-valvular infective endocarditis were not well characterized compared to uni-valvular endocarditis.
Observational (n=77)
Answers are grounded in this paper and cite their sources.
Supports heightened vigilance for multi-valvular involvement in native valve IE; leaves open optimal management strategies.
OBJECTIVE: Seventy-seven cases of native valve infective endocarditis as determined by the Duke criteria, were reviewed to determine the incidence and clinical features of multi-valvular endocarditis. METHODS: Fourteen of 77 patients (18%) had multi-valvular endocarditis most commonly involving the mitral and aortic valves. Staphylococcus aureus (43%) and viridans streptococci (36%) were the most common organisms causing multi-valvular endocarditis. RESULTS: Definite or probable vegetations were found in 50% of the patients by two-dimensional transthoracic echocardiograph and/or transesophageal echocardiograph, and possible vegetations were detected in 21%. The overall mortality in our series was 21%; 29% underwent valve replacement and 50% were treated medically. The major complications of multi-valvular endocarditis were congestive heart failure (64%), acute renal failure (50%), embolic events (21%), and splenic abscess/infarcts (21%). CONCLUSIONS: Our data suggests complications of multi-valvular endocarditis, compared with uni-valvular endocarditis are similar except for heart failure. Heart failure is statistically more common in multi-valvular endocarditis (P < or = 0.002).
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Kim et al. (2000) conducted an observational in Native valve infective endocarditis (n=77). Multi-valvular endocarditis vs. Uni-valvular endocarditis was evaluated on Heart failure (p=<=0.002). Multi-valvular endocarditis was associated with a significantly higher rate of congestive heart failure compared with uni-valvular endocarditis (64% vs unstated; P<=0.002).
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