Key result
ACE gene DD genotype is linked to ~3.4-fold higher cardiovascular disease risk.
Why the study?
Genetics and polymorphisms are thought to play an important role in the occurrence and progression of cardiovascular diseases, but their specific impact requires investigation.
Case-Control (n=100)
Yes
Should not change practice; leaves open whether ACE variants improve cardiovascular risk prediction.
Cardiovascular diseases (CVD) are the cause of the highest mortality rate among noncommunicable diseases, Some of the main risk factors for CVD include smoking, hypertension, high body mass index, lipid metabolism disorders, and diabetes mellitus, according to emerging evidence, Genetics and polymorphisms are thought to play an important role in the occurrence and progression of CVD. A number of 100 subjects were involved in this investigation, 70 of them with CVDs and the other 30 healthy individuals were used as control. The study was conducted to find out the importance of ACE gene polymorphism and biochemical variables in CVDs patients. In addition, the study aimed to investigate the effect of gene polymorphism on CVDs. The comparisons between genotypic frequency of ACE gene polymorphism in control and CVDs patients showed a significant increase (p≤0.005) in DD, ID genotype in CVDs patients compared to control , where II genotype significant decreased in CVDs patients compared to control. Our results show insertion mutation at 550bp only in CVDs patients, this mutation not show in other research.
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AlBayati et al. (2022) conducted a case-control in Cardiovascular diseases (n=100). ACE I/D polymorphism (DD genotype) vs. Healthy controls was evaluated on Presence of ACE gene DD genotype (OR 3.3913, 95% CI 1.0603 to 10.8466, p=0.0395). The ACE gene DD genotype was associated with increased cardiovascular disease risk (OR 3.3913), and a novel 550bp insertion was identified exclusively in the patient cohort.
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