Key result
The ACE D allele was significantly associated with an increased risk of coronary artery disease (OR 6.8; 95% CI 4.4-10).
Why the study?
Is the ACE I/D polymorphism associated with an increased risk of coronary artery disease in a Tunisian population?
Population
145 Tunisian patients with symptomatic coronary artery disease and a control group of 300 people matched for…
Comparison
ACE I/D polymorphisms (specifically the D allele) vs Controls without CAD / absence of the risk allele
Design
Case-control
Authors
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May inform CAD risk stratification in Tunisians; extends prior associations but remains hypothesis-generating pending replication.
Case-Control (n=445)
Is the ACE I/D polymorphism associated with an increased risk of coronary artery disease in a Tunisian population?
Odds Ratio: 6.8 (95% CI 4.4–10)
The ACE D allele is associated with a significantly increased risk of coronary artery disease in a Tunisian population, a risk that is further potentiated by traditional cardiovascular risk factors.
Amara et al. (2016) conducted a case-control in Coronary artery disease (n=445). ACE I/D polymorphisms vs. Age- and sex-matched controls was evaluated on Coronary artery disease (OR 6.8, 95% CI 4.4-10). The ACE D allele was significantly associated with an increased risk of coronary artery disease (OR 6.8; 95% CI 4.4-10).
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