Key result
The ACE DD genotype was significantly associated with the presence of coronary artery disease in Egyptian patients compared to healthy controls (OR 0.419; 95% CI 0.2-0.8; P=0.004).
Why the study?
Is the ACE insertion/deletion polymorphism associated with the presence of coronary artery disease in Egyptian patients?
Case-Control (n=251)
Is the ACE insertion/deletion polymorphism associated with the presence of coronary artery disease in Egyptian patients?
Odds Ratio: 0.419 (95% CI 0.2–0.8)
p-value: p=0.004
The ACE D allele and DD genotype are associated with an increased susceptibility to coronary artery disease and higher levels of Lp(a) and IL-6 in Egyptian patients.
ACE DD genotype association with CAD in this Egyptian case-control study should not yet change practice; leaves open need for prospective validation.
Angiotensin-I-converting enzyme (ACE) insertion/deletion (I/D) polymorphism has been associated with the genetic susceptibility to coronary artery disease (CAD) and also with the lipid profile in different populations. One hundred and eight Egyptian patients with CAD and one hundred forty three unrelated healthy subjects were included in the study. ACE I/D polymorphism was detected by polymerase chain reaction. We investigated the association between I/D polymorphism of the ACE gene and the presence of CAD as well as its association with hypertension in the patients. Serum levels of lipoprotein (a), Lp (a), and interleukin-6 (IL-6) were estimated in the patients as well as in the healthy subjects. Increased frequency of D allele and DD genotype as well as decreased frequency of I allele and ID genotype were found in CAD patients compared to healthy subjects (P = .004, OR= 0.419, 95% CI (.2 - .8), for DD genotype), (P = .008, OR= 0.475, 95% CI (0.270.84), for D allele). Higher levels of both Lp (a) and IL-6 were observed in CAD patients compared to control subjects (P = .0012, P = .0346, respectively). No association was
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Abdel -Aziz Fatouh Abdel-Aziz (2012) conducted a case-control in Coronary Artery Disease (n=251). ACE insertion/deletion (I/D) polymorphism vs. Healthy subjects was evaluated on Presence of coronary artery disease (OR 0.419, 95% CI 0.2-0.8, p=0.004). The ACE DD genotype was significantly associated with the presence of coronary artery disease in Egyptian patients compared to healthy controls (OR 0.419; 95% CI 0.2-0.8; P=0.004).
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