Key result
The D allele frequency of the ACE gene was significantly higher in Turkish patients with coronary artery disease compared to controls (0.733 vs 0.612; p=0.002).
Why the study?
Is the ACE gene I/D polymorphism associated with coronary artery disease in a Turkish population?
Case-Control (n=325)
Is the ACE gene I/D polymorphism associated with coronary artery disease in a Turkish population?
Absolute Event Rate: 0.733% vs 0.612%
p-value: p=0.002
The D allele of the ACE gene is significantly associated with coronary artery disease, myocardial infarction (specifically inferior MI), and hypertension in a Turkish population.
Does not support routine ACE genotyping for CAD risk; extends prior associations but remains hypothesis-generating.
Coronary artery disease (CAD) is a multifactorial disease in which genetic and environmental factors play an important role. These factors differ in each population. This study was carried out to determine whether there is an association between insertion/deletion (I/D) polymorphism and CAD in Turkish patients from Ankara. An I/D polymorphism in intron 16 of the gene coding for the angiotensin-converting enzyme (ACE) has been used to study the role of this gene in the aetiology of coronary atherosclerosis and hypertension. As there are no existing data for the Turkish population, we studied the I/D polymorphism of the ACE gene in 218 patients with CAD and 107 controls. Polymerase chain reaction (PCR) was used for genotyping the I and D alleles. The DD polymorphism of the ACE gene was significantly different between CAD subjects (0.733) and controls (0.612) (p=0.002). The observed heterozygosity was 29.3% and 43.9% and D allele frequency was 0.733 and 0.612, respectively. There was a significantly higher D allele (p=0.03) in 111 patients with myocardial infarction (MI) compared with controls. Furthermore, MI localization also gave a significance of p=0.002 for inferior MI but not for anterior MI (p=0.83). Forty-three hypertension patients had a D allele frequency of 0.767 which was significantly different from control (p=0.01). These data provide further evidence for the association of D allele and CAD in a Turkish population.
No takes yet. Share an insight, caveat, or question.
Akar et al. (1998) conducted a case-control in Coronary artery disease (n=325). ACE gene insertion/deletion (I/D) polymorphism vs. Controls without coronary artery disease was evaluated on D allele frequency (p=0.002). The D allele frequency of the ACE gene was significantly higher in Turkish patients with coronary artery disease compared to controls (0.733 vs 0.612; p=0.002).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: