Key result
CRT linked to ~10 fewer apnea-hypopnea events per hour in chronic heart failure.
Why the study?
Sleep apnea may contribute to the progressive decline in heart failure, but the effect of treating sleep apnea on clinical outcomes in heart failure patients has not been tested in randomized trials.
Observational (n=55)
CRT may improve sleep apnea in device-eligible HF patients; extends resynchronization benefits to respiratory outcomes in randomized data.
One of the factors that contribute to the progressively declining course of heart failure could be sleep apnea. Whether treating sleep apnea improves the clinical outcomes of patients with heart failure needs to be tested in randomized clinical trials.
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WEXLER et al. (2005) conducted an observational in Chronic heart failure (n=55). Cardiac resynchronization therapy (CRT) vs. Baseline (pre-intervention) was evaluated on Apnea-hypopnea index (AHI) in events per hour (p=<0.001). Cardiac resynchronization therapy significantly reduced the median apnea-hypopnea index from 33.4 to 23.4 events per hour (p<0.001) over 3 months in patients with chronic heart failure.
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