Hiccups: A Symptom of Hyponatremia to Remember

Objective: Hyponatremia represents a common electrolyte disorder with heterogeneous clinical manifestations and etiology-driven management strategies; however, its association with hiccups remains sparsely reported. This case report highlights that we aim to emphasize that persistent hiccups can serve as an unusual manifestation of hyponatremia.Case Report: In this case report, we describe a patient presenting with a 10-day history of persistent hiccups and a 2-day course of nausea and vomiting, found to have a serum sodium level of 118 mEq/L and a chloride level of 85 mEq/L upon admission. Serum glucose, BUN, transaminases, and creatinine levels were within normal limits. On admission, serum osmolarity was calculated as 247. Following volume repletion and the subsequent correction of hyponatremia, the patient’s hiccups completely resolved.Conclusion: Hyponatremia is a prevalent electrolyte disorder with clinical manifestations spanning from mild fatigue to coma. Given its rarer presentation, clinicians must keep hyponatremia in mind as a potential etiology in patients with persistent hiccups.