Key result
Insulin pretreatment accelerates recovery from hyperkalemia-induced QRS widening in an isolated heart model.
Why the study?
The mechanisms underlying hyperkalemia-induced ECG abnormalities and the effect of insulin on recovery from QRS complex widening were not fully elucidated.
p-value: p=<0.05
Insulin may aid hyperkalemia recovery in this model; leaves open translation to mammalian or human care.
Hyperkalemia is one of the most common electrolyte disorders. By injecting various concentrations of potassium chloride (KCl) solutions intravenously into bullfrogs, we demonstrated characteristic electrocardiogram (ECG) abnormalities of hyperkalemia in frog hearts. The widened QRS complexes induced by 100 mM KCl injection were accompanied by an increase in the resting membrane potential in cardiomyocytes and a decreased slope of phase 0 in the action potential. Recording both ECG waveforms and the cardiac action potential enabled us to reveal the mechanisms of hyperkalemia-induced ECG abnormalities. Additionally, pre-treatment with insulin, a powerful stimulator of Na+/K+-ATPase activity, significantly accelerated the recovery from the widened QRS complexes in the ECG, demonstrating a pronounced shift of extracellular potassium ions into the intracellular space.
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YEOH et al. (2021) studied Hyperkalemia (n=17). Insulin vs. External solution alone was evaluated on Recovery of QRS duration after 100 mM KCl injection (p=<0.05). Pre-treatment with insulin significantly accelerated the recovery from hyperkalemia-induced QRS complex widening in a frog heart model compared to control.
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