Why the study?
Does regional hyperkalemia induce ventricular conduction delay and arrhythmias in a canine model?
Population
37 intact anesthetized dogs
Design
Preclinical
Follow-up
up to 20 minutes
Authors
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Supports hyperkalemia-driven reentry in ischemia models; leaves open human translation.
Does regional hyperkalemia induce ventricular conduction delay and arrhythmias in a canine model?
Regional hyperkalemia in a canine model causes profound epicardial conduction depression and reentry, providing a mechanistic basis for ischemia-induced ventricular arrhythmias.
Ettinger et al. (1973) studied this question.
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